Journal article
Restrictive versus liberal fluid therapy for major abdominal surgery
PS Myles, R Bellomo, T Corcoran, A Forbes, P Peyton, D Story, C Christophi, K Leslie, S McGuinness, R Parke, J Serpell, MTV Chan, T Painter, S McCluskey, G Minto, S Wallace
New England Journal of Medicine | Published : 2018
Abstract
BACKGROUND Guidelines to promote the early recovery of patients undergoing major surgery recommend a restrictive intravenous-fluid strategy for abdominal surgery. However, the supporting evidence is limited, and there is concern about impaired organ perfusion. METHODS In a pragmatic, international trial, we randomly assigned 3000 patients who had an increased risk of complications while undergoing major abdominal surgery to receive a restrictive or liberal intravenous-fluid regimen during and up to 24 hours after surgery. The primary outcome was disability-free survival at 1 year. Key secondary outcomes were acute kidney injury at 30 days, renal-replacement therapy at 90 days, and a composit..
View full abstractGrants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
Supported by a grant (ID1043755) from the Australian National Health and Medical Research Council (NHMRC), the Australian and New Zealand College of Anaesthetists, Monash University, a grant (ID14/222) from the Health Research Council of New Zealand, and the United Kingdom National Institute of Health Research. Drs. Myles and Bellomo are supported by Australian NHMRC Practitioner Fellowships.