Systemic hypertension is not protective against chronic intraocular pressure elevation in a rodent model

Anna K van Koeverden; Zheng He; Christine TO Nguyen; Algis J Vingrys; Bang V Bui

Journal article

Systemic hypertension is not protective against chronic intraocular pressure elevation in a rodent model

Anna K van Koeverden, Zheng He, Christine TO Nguyen, Algis J Vingrys, Bang V Bui

SCIENTIFIC REPORTS | NATURE PUBLISHING GROUP | Published : 2018

DOI: 10.1038/s41598-018-25264-4

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Abstract

High intraocular pressure is the most well documented glaucoma risk factor; however many patients develop and/or show progression of glaucoma in its absence. It is now thought that in some instances, ocular perfusion pressure (blood pressure - intraocular pressure) may be as important as intraocular pressure alone. Thus, systemic hypertension would be protective against glaucoma. Epidemiological studies, however, are inconclusive. One theory of why hypertension may not protect against elevated intraocular pressure in spite of increasing ocular perfusion pressure is that with time, morphological changes to the vasculature and autoregulatory failure outweigh the benefits of improved perfusion ..

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University of Melbourne Researchers

Bang Bui Author Optometry and Vision Sciences

Algis Vingrys Author Optometry and Vision Sciences

Barry Cole Author Optometry and Vision Sciences

Christine Nguyen Author Optometry and Vision Sciences

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Grants

Awarded by Australian Research Council

Awarded by Australian National Health and Medical Research Council

Funding Acknowledgements

This research was supported by the Australian Research Council (FT130100338), The Australian National Health and Medical Research Council (1046203) and an Australian Postgraduate award from the Australian Government.