Journal article
Airway responsiveness to methacholine and incidence of COPD: An international prospective cohort study
A Marcon, F Locatelli, D Keidel, AB Beckmeyer-Borowko, I Cerveri, SC Dharmage, E Fuertes, J Garcia-Aymerich, J Heinrich, M Imboden, C Janson, A Johannessen, B Leynaert, S Pascual Erquicia, G Pesce, E Schaffner, C Svanes, I Urrutia, D Jarvis, NM Probst-Hensch Show all
Thorax | BMJ PUBLISHING GROUP | Published : 2018
Abstract
Background It has been debated, but not yet established, whether increased airway responsiveness can predict COPD. Recognising this link may help in identifying subjects at risk. Objective We studied prospectively whether airway responsiveness is associated with the risk of developing COPD. Methods We pooled data from two multicentre cohort studies that collected data from three time points using similar methods (European Community Respiratory Health Survey and Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults). We classified subjects (median age 37 years, 1st-3rd quartiles: 29-44) by their level of airway responsiveness using quintiles of methacholine dose-response s..
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Awarded by Generalitat de Catalunya
Funding Acknowledgements
The ALEC Study is funded by the European Union's Horizon 2020 Research and Innovation programme under grant agreement no. 633212. ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya. The SAPALDIA cohort has been funded since 1991 primarily by the Swiss National Science Foundation (grants no 33CS30-148470/1&2, 33CSCO-134276/1, 33CSCO-108796, 324730_135673, 3247BO-104283, 3247BO-104288, 3247BO-104284, 3247-065896, 3100-059302, 3200-052720, 3200-042532, 4026-028099, PMPDP3_129021/1, PMPDP3_141671/1). Other national funders who supported data collection in the original studies are listed in the supplement.