Self-Reported Physical Activity is Associated with Tau Burden Measured by Positron Emission Tomography

BM Brown; SR Rainey-Smith; V Dore; JJ Peiffer; SC Burnham; SM Laws; K Taddei; D Ames; CL Masters; CC Rowe; RN Martins; VL Villemagne

Journal article

Self-Reported Physical Activity is Associated with Tau Burden Measured by Positron Emission Tomography

BM Brown, SR Rainey-Smith, V Dore, JJ Peiffer, SC Burnham, SM Laws, K Taddei, D Ames, CL Masters, CC Rowe, RN Martins, VL Villemagne

Journal of Alzheimer S Disease | IOS PRESS | Published : 2018

DOI: 10.3233/JAD-170998

Abstract

Numerous animal studies have reported exercise reduces the accumulation of Alzheimer's disease pathology, including amyloid-β (Aβ) and tau. Furthermore, we previously reported a relationship between higher levels of physical activity (PA) and lower brain Aβ burden in a human population. The recent advent of tau positron emission tomography (PET) tracers enables us to extend our investigations into the evaluation of the relationship between PA and brain tau burden. Utilizing data from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, we have examined the cross-sectional relationship between habitual PA and PET-quantified tau burden. Forty-three cognitively healthy older adults we..

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University of Melbourne Researchers

David Ames Author

Christopher Rowe Author

Victor Villemagne Author

Grants

Awarded by Hollywood Private Hospital Research Foundation

Funding Acknowledgements

BB is supported by NHMRC National Institute of Dementia Research (GNT1097105). Funding for the AIBL study is provided by the CSIRO Flagship Collaboration Fund and the Science and Industry Endowment Fund (SIEF) in partnership with Edith Cowan University (ECU), The Florey Institute of Neuroscience and Mental Health, Alzheimer's Australia (AA), National Ageing Research Institute (NARI), Austin Health, CogState Ltd., Hollywood Private Hospital, and Sir Charles Gairdner Hospital. The study also receives funding from the National Health and Medical Research Council (NHMRC), the Dementia Collaborative Research Centres program (DCRC2) and the Australian Alzheimer's Research Foundation, and Operational Infrastructure Support from the Government of Victoria. The authors also acknowledge the financial support of the CRC for Mental Health. The Cooperative Research Centre (CRC) program is an Australian Government Initiative.