Investigating Viral Interference Between Influenza A Virus and Human Respiratory Syncytial Virus in a Ferret Model of Infection
Kok Fei Chan, Louise A Carolan, Daniil Korenkov, Julian Druce, James McCaw, Patrick C Reading, Ian G Barr, Karen L Laurie
JOURNAL OF INFECTIOUS DISEASES | OXFORD UNIV PRESS INC | Published : 2018
Epidemiological studies have observed that the seasonal peak incidence of influenza virus infection is sometimes separate from the peak incidence of human respiratory syncytial virus (hRSV) infection, with the peak incidence of hRSV infection delayed. This is proposed to be due to viral interference, whereby infection with one virus prevents or delays infection with a different virus. We investigated viral interference between hRSV and 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) in the ferret model. Infection with A(H1N1)pdm09 prevented subsequent infection with hRSV. Infection with hRSV reduced morbidity attributed to infection with A(H1N1)pdm09 but not infection, even when an incr..View full abstract
This work was supported by the Australian Government Department of Health (to the Melbourne WHO Collaborating Centre for Reference and Research on Influenza) and the Royal Melbourne Hospital Home Lottery.