Journal article

A decade of changes in brain volume and cognition

Rowa Aljondi, Cassandra Szoeke, Chris Steward, Paul Yates, Patricia Desmond

BRAIN IMAGING AND BEHAVIOR | SPRINGER | Published : 2019

Abstract

Brain atrophy can occur several decades prior to onset of cognitive impairments. However, few longitudinal studies have examined the relationship between brain volume changes and cognition over a long follow-up period in healthy elderly women. In the present study we investigate the relationship between whole brain and hippocampal atrophy rates and longitudinal changes in cognition, including verbal episodic memory and executive function, in older women. We also examine whether baseline brain volume predicts subsequent changes in cognitive performance over a 10-year period. A total of 60 individuals from the population-based Women's Healthy Ageing Project with a mean age at baseline of 59 ye..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by Alzheimer's Association


Funding Acknowledgements

This study is funded by the National Health and Medical Research Council (NHMRC Grants 547500, 1032350 & 1062133), Ramaciotti Foundation, Australian Healthy Ageing Organisation, the Brain Foundation, the Alzheimer's Association (NIA320312), Australian Menopausal Society, Bayer Healthcare, Shepherd Foundation, Scobie and Claire Mackinnon Foundation, Collier Trust Fund, J.O. & J.R. Wicking Trust, Mason Foundation and the Alzheimer's Association of Australia. Inaugural funding was provided by VicHealth and the NHMRC. The Principal Investigator of WHAP (CSz) is supported by the National Health and Medical Research Council.