Journal article
Genome-wide association studies for diabetic macular edema and proliferative diabetic retinopathy
Patricia S Graham, Georgia Kaidonis, Sotoodeh Abhary, Mark C Gillies, Mark Daniell, Rohan W Essex, John H Chang, Stewart R Lake, Bishwanath Pal, Alicia J Jenkins, Alex W Hewitt, Ecosse L Lamoureux, Philip G Hykin, Nikolai Petrovsky, Matthew A Brown, Jamie E Craig, Kathryn P Burdon
BMC MEDICAL GENETICS | BMC | Published : 2018
Abstract
BACKGROUND: Diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) are sight-threatening complications of diabetes mellitus and leading causes of adult-onset blindness worldwide. Genetic risk factors for diabetic retinopathy (DR) have been described previously, but have been difficult to replicate between studies, which have often used composite phenotypes and been conducted in different populations. This study aims to identify genetic risk factors for DME and PDR as separate complications in Australians of European descent with type 2 diabetes. METHODS: Caucasian Australians with type 2 diabetes were evaluated in a genome-wide association study (GWAS) to compare 270 DME c..
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Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
This research was funded by the National Health and Medical Research Council of Australia (GNT 595918). The funding body played no role in the design of the study, data collection, analysis, interpretation or writing of the manuscript.