Journal article

Genome-wide association studies for diabetic macular edema and proliferative diabetic retinopathy

Patricia S Graham, Georgia Kaidonis, Sotoodeh Abhary, Mark C Gillies, Mark Daniell, Rohan W Essex, John H Chang, Stewart R Lake, Bishwanath Pal, Alicia J Jenkins, Alex W Hewitt, Ecosse L Lamoureux, Philip G Hykin, Nikolai Petrovsky, Matthew A Brown, Jamie E Craig, Kathryn P Burdon

BMC MEDICAL GENETICS | BMC | Published : 2018

Abstract

BACKGROUND: Diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) are sight-threatening complications of diabetes mellitus and leading causes of adult-onset blindness worldwide. Genetic risk factors for diabetic retinopathy (DR) have been described previously, but have been difficult to replicate between studies, which have often used composite phenotypes and been conducted in different populations. This study aims to identify genetic risk factors for DME and PDR as separate complications in Australians of European descent with type 2 diabetes. METHODS: Caucasian Australians with type 2 diabetes were evaluated in a genome-wide association study (GWAS) to compare 270 DME c..

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