Journal article
Low-dose levothyroxine reduces intrahepatic lipid content in patients with type 2 diabetes mellitus and NAFLD
E Bruinstroop, R Dalan, Y Cao, YM Bee, K Chandran, LW Cho, SB Soh, EK Teo, SA Toh, MKS Leow, RA Sinha, SA Sadananthan, N Michael, HM Stapleton, C Leung, PW Angus, SK Patel, LM Burrell, SC Lim, CF Sum Show all
Journal of Clinical Endocrinology and Metabolism | ENDOCRINE SOC | Published : 2018
Abstract
Context Nonalcoholic fatty liver disease (NAFLD) is highly prevalent in patients with type 2 diabetes mellitus (T2DM) and associated with significant morbidity and mortality. Thyroid hormone (TH) increases β-oxidation of fatty acids and decreases intrahepatic lipid content (IHLC) in rodents with NAFLD. Objective We investigated the possibility of low intrahepatic TH concentration in NAFLD and studied the effect of TH treatment in humans. Design/Setting This was a phase 2b single-arm study in six hospitals in Singapore. Intrahepatic thyroid hormone concentrations were measured in rats with induced NAFLD. Patients Euthyroid patients with T2DM and steatosis measured by ultrasonography. Interven..
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Grants
Awarded by Koninklijke Nederlandse Akademie van Wetenschappen
Funding Acknowledgements
The animal research was supported by a National Health and Medical Research Council of Australia Grant and scholarship [1029990 (to P.W.A. and C.L.) and 629025 (to C.L.)]. The human intervention study was sponsored by the Tanoto Initiative for Diabetes Research (to P.M.Y.). E.B. was funded by a Niels Stensen Fellowship, Ter Meulen Grant of the Royal Netherlands Academy of Arts and Sciences, and Catherine van Tussenbroekfonds (A3-2; www.evtfonds.nl).