Journal article
The complement system contributes to functional antibody-mediated responses induced by immunization with Plasmodium falciparum malaria sporozoites
MC Behet, L Kurtovic, GJ van Gemert, CM Haukes, R Siebelink-Stoter, W Graumans, MG van de Vegte-Bolmer, A Scholzen, JD Langereis, DA Diavatopoulos, JG Beeson, RW Sauerwein
Infection and Immunity | AMER SOC MICROBIOLOGY | Published : 2018
DOI: 10.1128/IAI.00920-17
Open access
Abstract
Long-lasting and sterile homologous protection against malaria can be achieved by the exposure of malaria-naive volunteers under chemoprophylaxis to Plasmodium falciparum-infected mosquitoes (chemoprophylaxis and sporozoite [CPS] immunization). While CPS-induced antibodies neutralize sporozoite infectivity in vitro and in vivo, antibody-mediated effector mechanisms are still poorly understood. Here, we investigated whether complement contributes to CPS-induced preerythrocytic immunity. Sera collected before and after CPS immunization in the presence of active or inactive complement were assessed for the recognition of homologous NF54 and heterologous NF135.C10 sporozoites, complement fixatio..
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Awarded by Bill and Melinda Gates Foundation
Funding Acknowledgements
The clinical trials from which samples were used in the present study were funded by the Bill and Melinda Gates Foundation (grants OPP1080385 and OPP1091355). The funder had no role in study design, data collection, analysis or interpretation of the data, the preparation of the manuscript, or the decision to submit the work for publication. M.C.B. is supported by a Nijmegen Institute for Infection, Inflammation, and Immunity (N4i) Ph.D. scholarship.