Journal article
Consensus guidelines for the use and interpretation of angiogenesis assays
Patrycja Nowak-Sliwinska, Kari Alitalo, Elizabeth Allen, Andrey Anisimov, Alfred C Aplin, Robert Auerbach, Hellmut G Augustin, David O Bates, Judy R van Beijnum, R Hugh F Bender, Gabriele Bergers, Andreas Bikfalvi, Joyce Bischoff, Barbara C Boeck, Peter C Brooks, Federico Bussolino, Bertan Cakir, Peter Carmeliet, Daniel Castranova, Anca M Cimpean Show all
ANGIOGENESIS | SPRINGER | Published : 2018
Abstract
The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines o..
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Awarded by Dutch Cancer Society
Awarded by European Research Council (ERC) Starting Research Grant
Awarded by Advanced Research Grant
Awarded by Federal Government Belgium grant
Awarded by Swiss National Science Foundation
Awarded by National Institutes of Health
Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
Awarded by NATIONAL CANCER INSTITUTE
Awarded by NATIONAL EYE INSTITUTE
Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Awarded by NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
Funding Acknowledgements
We apologize for not being able to cite the work of all other studies related to this topic because of space restrictions. This work was supported by funding from: Dutch Cancer Society (VU2012-5480 to JRvB and AWG; VU2014-7234 to AWG and PNS); European Research Council (ERC) Starting Research Grant (EU-ERC680209, to PNS); Advanced Research Grant (EU-ERC269073 to PC); FWO Postdoctoral Fellowships (to JK); Federal Government Belgium grant (IUAP P7/03 to PC); long-term structural Methusalem funding by the Flemish Government (to PC); Research Foundation Flanders (FWO, to PC); Foundation Leducq Transatlantic Network (ARTEMIS, to PC); Foundation Against Cancer (to PC); AXA Research Fund (to PC); INSERM recurrent funding (to AB); Association pour la Recherche sur le Cancer (ARC, to AB); Ligue Nationale du Cancer (to AB); Swiss National Science Foundation (31003A_159824 and CRSII3_154499 to CR); British Heart Foundation (to AMR and ND). Research reported in this manuscript was supported by the National Institutes of Health under Award Nos: R01 HL096384, R01 HL27030 to JB; R01 AR069038, R01 HL128452 and R21 AI123883 to JMM-M; R01 CA188404 and R01 CA201537 to GB. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.