Selective inhibition of the synthesis of mouse satellite DNA by dehydroheliotridine.
Chem Biol Interact | Published : 1972
Dehydroheliotridine, the major unbound, relatively stable metabolite of the heliotrine-based alkaloids, lasiocarpine and heliotrine, has a selective depressant effect on the incorporation of [3H]thymidine into mouse satellite DNA. In view of recently published data on the localization of satellite sequences in the heterochromatin it is considered possible that the preferential attack on the pericentromeric heterochromatin previously observed in chromosome breakage studies with dehydroheliotridine may be due to its effects on the synthesis of satellite DNA. © 1972.