Journal article

STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus

Elaine F Remmers, Robert M Plenge, Annette T Lee, Robert R Graham, Geoffrey Hom, Timothy W Behrens, Paul IW de Bakker, Julie M Le, Hye-Soon Lee, Franak Batliwalla, Wentian Li, Seth L Masters, Matthew G Booty, John P Carulli, Leonid Padyukov, Lars Alfredsson, Lars Klareskog, Wei V Chen, Christopher I Amos, Lindsey A Criswell Show all

NEW ENGLAND JOURNAL OF MEDICINE | MASSACHUSETTS MEDICAL SOC | Published : 2007

Abstract

BACKGROUND: Rheumatoid arthritis is a chronic inflammatory disease with a substantial genetic component. Susceptibility to disease has been linked with a region on chromosome 2q. METHODS: We tested single-nucleotide polymorphisms (SNPs) in and around 13 candidate genes within the previously linked chromosome 2q region for association with rheumatoid arthritis. We then performed fine mapping of the STAT1-STAT4 region in a total of 1620 case patients with established rheumatoid arthritis and 2635 controls, all from North America. Implicated SNPs were further tested in an independent case-control series of 1529 patients with early rheumatoid arthritis and 881 controls, all from Sweden, and in a..

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University of Melbourne Researchers