Journal article

Disease-associated amyloid and misfolded protein aggregates activate the inflammasome

Seth L Masters, Luke AJ O'Neill

TRENDS IN MOLECULAR MEDICINE | ELSEVIER SCI LTD | Published : 2011

Abstract

The pathogenesis of type 2 diabetes, Alzheimer's disease and amyotrophic lateral sclerosis continues to be debated. Recently, the inflammasome protein complex has been shown to be a key regulator of IL-1β, a cytokine implicated in each of these diseases. In all three cases, it is now apparent that unique protein aggregates caused by inappropriate oligomerization or misfolding are sensed by the inflammasome, providing a unifying mechanism for this IL-1β production. What evolved as an innate defense against infection-related particles, therefore, now seems to be a driving force for inflammation in these diseases. This review discusses the basic research behind these findings and the potential ..

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University of Melbourne Researchers