Journal article

Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK

Francine FS Ke, Hannah K Vanyai, Angus D Cowan, Alex RD Delbridge, Lachlan Whitehead, Stephanie Grabow, Peter E Czabotar, Anne K Voss, Andreas Strasser

Cell | CELL PRESS | Published : 2018


Awarded by National Health and Medical Research Council (NHMRC)

Awarded by NHMRC

Awarded by Leukemia and Lymphoma Society (SCOR Grant)

Funding Acknowledgements

We thank Drs. T. Kaufmann, D.C.S. Huang, S.J. Korsmeyer, and C. Thompson for mice; C. D'Alessando and G. Siciliano for expert animal care; WEHI Histology and Imaging services department; Z. Liu and R. Salvamoser for lysates for western blots; Drs. J. Vince and N. Lalaoui for antibodies; A. Wardak for western blot optimization; S. Monard for FACS assistance; and D. Anbarci for photography of histological slides for analysis. We also thank Professor P.M. Colman for discussions and comments regarding the BOK structure and the beamline staff at the Australian Synchrotron. Crystallization experiments were performed at the Bio21 C3 Collaborative Crystallisation Centre. This work was supported by grants and fellowships from the Cancer Council Victoria (F.F.S.K., S.G.), the Lady Tata Memorial Trust (S.G.) the Leukaemia Foundation Australia (F.F.S.K., S.G.), Australian Government Postgraduate Award (H.K.V.), the National Health and Medical Research Council (NHMRC Program Grant 1016701 to A.S.; NHMRC Project grant 1051078 to A.K.V.; NHMRC project grant 1079706 to P.E.C.; and NHMRC Fellowships 1020363 to A.S., 575512 and 1081421 to A.K.V., and 1079700 to P.E.C.), the Leukemia and Lymphoma Society (SCOR Grant 7001-03; to A.S.), and the operational infrastructure grants through the Australian Government IRIISS and the Victorian State Government OIS.