Journal article

Toll-Like Receptors Drive Specific Patterns of Tolerance and Training on Restimulation of Macrophages

Suzanne K Butcher, Christine E O'Carroll, Christine A Wells, Ruaidhri J Carmody

FRONTIERS IN IMMUNOLOGY | FRONTIERS MEDIA SA | Published : 2018

Abstract

Tolerance is a long-recognized property of macrophages that leads to an altered response to repeated or chronic exposure to endotoxin. The physiological role of tolerance is to limit the potential damage to host tissue that may otherwise result from prolonged production of pro-inflammatory cytokines. Tolerance is induced by all toll-like receptor (TLR) ligands tested to date, however, tolerance induced by the TLR4 ligand lipopolysaccharide (LPS) is by far the best studied. LPS tolerance involves a global transcriptional shift from a pro-inflammatory response toward one characterized by the expression of anti-inflammatory and pro-resolution factors. Although largely reversible, LPS-tolerance ..

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Grants

Awarded by Medical Research Council


Awarded by Biotechnology and Biological Sciences Research Council


Awarded by COST Action Mye-EUNITER


Awarded by Australian Research Council


Funding Acknowledgements

The authors thank Tyrone Chen and Othmar Korn and the Stemformatics team for microarray normalization and visualization. The authors acknowledge the support of the Medical Research Council (MR/M010694/1) (RC), and the Biotechnology and Biological Sciences Research Council (BB/M003671/1) (RC) and the COST Action BM1404 Mye-EUNITER (www.mye-euniter.eu), supported by COST (European Cooperation in Science and Technology), and the Australian Research Council (FT150100330; SR1101002) (CW). SB is funded by a scholarship from the University of Melbourne.