Journal article

Toll-Like Receptors Drive Specific Patterns of Tolerance and Training on Restimulation of Macrophages

Suzanne K Butcher, Christine E O'Carroll, Christine A Wells, Ruaidhri J Carmody



Tolerance is a long-recognized property of macrophages that leads to an altered response to repeated or chronic exposure to endotoxin. The physiological role of tolerance is to limit the potential damage to host tissue that may otherwise result from prolonged production of pro-inflammatory cytokines. Tolerance is induced by all toll-like receptor (TLR) ligands tested to date, however, tolerance induced by the TLR4 ligand lipopolysaccharide (LPS) is by far the best studied. LPS tolerance involves a global transcriptional shift from a pro-inflammatory response toward one characterized by the expression of anti-inflammatory and pro-resolution factors. Although largely reversible, LPS-tolerance ..

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Awarded by Medical Research Council

Awarded by Biotechnology and Biological Sciences Research Council

Awarded by COST Action Mye-EUNITER

Awarded by Australian Research Council

Funding Acknowledgements

The authors thank Tyrone Chen and Othmar Korn and the Stemformatics team for microarray normalization and visualization. The authors acknowledge the support of the Medical Research Council (MR/M010694/1) (RC), and the Biotechnology and Biological Sciences Research Council (BB/M003671/1) (RC) and the COST Action BM1404 Mye-EUNITER (, supported by COST (European Cooperation in Science and Technology), and the Australian Research Council (FT150100330; SR1101002) (CW). SB is funded by a scholarship from the University of Melbourne.