Sex-specific relevance of diabetes to occlusive vascular and other mortality: a collaborative meta-analysis of individual data from 980793 adults from 68 prospective studies

Louisa Gnatiuc; William G Herrington; Jim Halsey; Jaakko Tuomilehto; Xianghau Fang; Hyeon C Kim; Dirk DeBacquer; Annette J Dobson; Michael H Criqui; David R Jacobs; David A Leon; Sanne AE Peters; Hirotsugu Ueshima; Paul Sherliker; Richard Peto; Rory Collins; Rachel R Huxley; Jonathan R Emberson; Mark Woodward; Sarah Lewington; G De Backer; D De Bacquer; M Kornitzer; R Morris; SG Wannamethee; P Whincup; M Law; J Morris; N Wald; D Kromhout; A Benetos; L Guize; G Jensen; P Schnohr; P Jousilahti; P Puska; J Tuomilehto; E Vartiainen; A Aromaa; P Knekt; A Reunanen; N Borup Johansen; T Thomsen; C Bengtsson; C Bjorkelund; L Lissner; U Goldbourt; R Selmer; A Tverdal; T Meade; L Haheim; I Hjermann; I Holme; P Leren; P Ducimetiere; J Empana; G Assmann; H Schulte; G Davey Smith; C Hart; D Hole; H Tunstall-Pedoe; G Davey Smith; P Sweetnam; J Yarnell; E Arnesen; K Bonaa; H Tunstall-Pedoe; DA Leon; M Marmot; M Shipley; G Davey Smith; C Gillis; C Hart; D Hole; L Chambless; M Luszcz; SS Dhaliwal; TA Welborn; H Bartholomew; MW Knuiman; R Kronmal; PJ Nietert; SE Sutherland; DL Bachman; P Gazes; E Boyle; R Jackson; S MacMahon; R Norton; G Whitlock; R D'Agostino; D Levy; H Silbershatz; JD Curb; D Sharp; GG Giles; S Hashimoto; K Sakata; H Blackburn; D Jacobs; R Luepker; A Dobson; C Cox; R Broadhurst; M Hobbs; K Jamrozik; M Garcia-Palmieri; P Sorlie; J Keller; M Guasch-Ferre; F Hu; W Willett; H Eliassen; H Maegawa; A Okayama; H Ueshima; N Aoki; M Nakamura; ZL Wu; X Shifu; A Tamakoshi; P Sritara; DF Gu; CQ Jiang; TH Lam; SC Ho; J Woo; H Iso; A Kitamura; S Sato; T Murayama; Y Nishimoto; M Tomita; SH Jee; IS Kim; I Suh; H Ueshima; Y Kita; I Niki; H Iso; A Kitamura; Y Naito; S Sato; H Iso; A Kitamura; Y Naito; S Sato; A Hozawa; Y Imai; T Ohkubo; K Imai; C Date; T Nakayama; T Yokoyama; N Yoshiike; H Tanaka; Y Kita; A Nozaki; H Ueshima; H Horibe; M Kagaya; Y Matsutani; K Hughes; J Lee; D Heng; S Saitoh; K Shimamoto; WH Pan; SX Yao; S Lewington; S MacMahon; R Peto; A Aromaa; C Baigent; J Carstensen; Z Chen; R Clarke; R Collins; S Duffy; D Kromhout; J Neaton; N Qizilbash; A Rodgers; S Tominaga; S Tornberg; G Whitlock; D Bennett; D Gu; H Horibe; R Huxley; S MacMahon; WH Pan; A Rodgers; I Suh; H Ueshima; M Woodward; ZL Wu; XH Zhang

Journal article

Sex-specific relevance of diabetes to occlusive vascular and other mortality: a collaborative meta-analysis of individual data from 980793 adults from 68 prospective studies

Louisa Gnatiuc, William G Herrington, Jim Halsey, Jaakko Tuomilehto, Xianghau Fang, Hyeon C Kim, Dirk DeBacquer, Annette J Dobson, Michael H Criqui, David R Jacobs, David A Leon, Sanne AE Peters, Hirotsugu Ueshima, Paul Sherliker, Richard Peto, Rory Collins, Rachel R Huxley, Jonathan R Emberson, Mark Woodward, Sarah Lewington Show all

The Lancet Diabetes & Endocrinology | ELSEVIER SCIENCE INC | Published : 2018

DOI: 10.1016/S2213-8587(18)30079-2

Abstract

BACKGROUND: Several studies have shown that diabetes confers a higher relative risk of vascular mortality among women than among men, but whether this increased relative risk in women exists across age groups and within defined levels of other risk factors is uncertain. We aimed to determine whether differences in established risk factors, such as blood pressure, BMI, smoking, and cholesterol, explain the higher relative risks of vascular mortality among women than among men. METHODS: In our meta-analysis, we obtained individual participant-level data from studies included in the Prospective Studies Collaboration and the Asia Pacific Cohort Studies Collaboration that had obtained baseline in..

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University of Melbourne Researchers

Graham Giles Author Melbourne School of Population and Global Health

Grants

Awarded by National Institute on Aging (US National Institutes of Health)

Awarded by MRC Skills Development Fellowship

Awarded by British Heart Foundation

Funding Acknowledgements

The Prospective Studies Collaboration has been supported by the UK Medical Research Council (MRC), British Heart Foundation, Cancer Research UK, European Union BIOMED programme, National Institute on Aging (US National Institutes of Health) grant P01 AG17625-01, and Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU) overheads. Merck helped to support the 1996 meeting of collaborators. Sarah Lewington had a British Heart Foundation Fellowship to coordinate this project. Sanne A E Peters is supported by an MRC Skills Development Fellowship (MR/P014550/1). William G Herrington is supported by an MRC and Kidney Research UK Prof David Kerr Clinician Scientist Award. The University of Oxford MRC Population Health Research Unit is funded through a strategic partnership between the MRC and the University of Oxford.