Journal article

Multiple brain pathologies in dementia are common

M Woodward, IRA MacKenzie, GYR Hsiung, C Jacova, H Feldman

European Geriatric Medicine | Published : 2010

Abstract

Multiple pathological processes are common in those with dementia and can affect clinical presentations. This study defined the extent of multiple pathological processes at autopsy in a well-characterized dementia clinic population and determined their impact on cognitive deficits. Forty-five cases from the Canadian Collaborative Cohort of Related Dementia (ACCORD) were prospectively assigned one primary clinical diagnosis and up to one secondary clinical diagnosis. Neuropathological examination followed a uniform protocol including mandatory semiquantitative assessment of a wide range of pathological changes. Multiple significant pathologies were identified in 21 cases (46.7%) including 19 ..

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