Journal article
Trajectories of irregular word reading ability as a proxy for premorbid intelligence in Alzheimer's disease, mild cognitive impairment, and healthy aging: A longitudinal study
M Weinborn, RS Bucks, HR Sohrabi, SR Rainey-Smith, BM Brown, SL Gardener, A Gozt, D Christensen, G Savage, SM Laws, K Taddei, P Maruff, JS Robertson, KA Ellis, D Ames, CL Masters, CC Rowe, RN Martins
Psychological Assessment | AMER PSYCHOLOGICAL ASSOC | Published : 2018
DOI: 10.1037/pas0000565
Abstract
The ability to read irregularly spelled words is commonly used to estimate premorbid intelligence, as this ability has been thought to be resistant to early effects of neurodegenerative disorders. However, studies evaluating decline of this skill in Alzheimer's disease (AD) have produced conflicting results. Irregular word reading was assessed three times over 36 months in a large (N = 995) sample, including healthy control, AD, and Mild Cognitive Impairment (MCI) groups. At baseline, MCI and AD groups read correctly an average of 3.01 and 7.39 fewer words, respectively, than healthy controls. The MCI group's performance remained stable during the study, but the AD group declined. Importantl..
View full abstractGrants
Funding Acknowledgements
Funding for the AIBL study was provided by the CSIRO Flagship Collaboration Fund and the Science and Industry Endowment Fund in partnership with Edith Cowan University, The Florey Institute of Neuroscience and Mental Health, Alzheimer's Australia, National Ageing Research Institute, Austin Health, CogState Ltd., Hollywood Private Hospital, and Sir Charles Gairdner Hospital. The study also received funding from the National Health and Medical Research Council, the Dementia Collaborative Research Centres, the Australian Alzheimer's Research Foundation, and Operational Infrastructure Support from the Government of Victoria.