Resting-state functional brain networks in first-episode psychosis: A 12-month follow-up study
Eleni P Ganella, Caio Seguin, Christos Pantelis, Sarah Whittle, Bernhard T Baune, James Olver, G Paul Amminger, Patrick D McGorry, Vanessa Cropley, Andrew Zalesky, Cali F Bartholomeusz
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY | SAGE PUBLICATIONS LTD | Published : 2018
INTRODUCTION: Schizophrenia is increasingly conceived as a disorder of brain network connectivity and organization. However, reports of network abnormalities during the early illness stage of psychosis are mixed. This study adopted a data-driven whole-brain approach to investigate functional connectivity and network architecture in a first-episode psychosis cohort relative to healthy controls and whether functional network properties changed abnormally over a 12-month period in first-episode psychosis. METHODS: Resting-state functional connectivity was performed at two time points. At baseline, 29 first-episode psychosis individuals and 30 healthy controls were assessed, and at 12 months, 14..View full abstract
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Awarded by NHMRC
E.P.G. was supported by the University of Melbourne and CRC for Mental Health PhD top-up scholarship. C.P. was supported by NHMRC Senior Principal Research Fellowship (628386 and 1105825). A.Z. was supported by a NHMRC Career Development Fellowship (GNT1047648) S.W. was supported by a NHMRC Career Development Fellowship (ID: 1007716).