Resting-state functional brain networks in first-episode psychosis: A 12-month follow-up study

EP Ganella; C Seguin; C Pantelis; S Whittle; BT Baune; J Olver; GP Amminger; PD McGorry; V Cropley; A Zalesky; CF Bartholomeusz

Journal article

Resting-state functional brain networks in first-episode psychosis: A 12-month follow-up study

EP Ganella, C Seguin, C Pantelis, S Whittle, BT Baune, J Olver, GP Amminger, PD McGorry, V Cropley, A Zalesky, CF Bartholomeusz

Australian and New Zealand Journal of Psychiatry | SAGE PUBLICATIONS LTD | Published : 2018

DOI: 10.1177/0004867418775833

Abstract

Introduction: Schizophrenia is increasingly conceived as a disorder of brain network connectivity and organization. However, reports of network abnormalities during the early illness stage of psychosis are mixed. This study adopted a data-driven whole-brain approach to investigate functional connectivity and network architecture in a first-episode psychosis cohort relative to healthy controls and whether functional network properties changed abnormally over a 12-month period in first-episode psychosis. Methods: Resting-state functional connectivity was performed at two time points. At baseline, 29 first-episode psychosis individuals and 30 healthy controls were assessed, and at 12 months, 14..

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University of Melbourne Researchers

Caio Pimentel Seguin Author

Christos Pantelis Author

Sarah Whittle Author

Bernhard Baune Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

E.P.G. was supported by the University of Melbourne and CRC for Mental Health PhD top-up scholarship. C.P. was supported by NHMRC Senior Principal Research Fellowship (628386 and 1105825). A.Z. was supported by a NHMRC Career Development Fellowship (GNT1047648) S.W. was supported by a NHMRC Career Development Fellowship (ID: 1007716).