Resting-state functional brain networks in first-episode psychosis: A 12-month follow-up study

Eleni P Ganella; Caio Seguin; Christos Pantelis; Sarah Whittle; Bernhard T Baune; James Olver; G Paul Amminger; Patrick D McGorry; Vanessa Cropley; Andrew Zalesky; Cali F Bartholomeusz

Journal article

Resting-state functional brain networks in first-episode psychosis: A 12-month follow-up study

Eleni P Ganella, Caio Seguin, Christos Pantelis, Sarah Whittle, Bernhard T Baune, James Olver, G Paul Amminger, Patrick D McGorry, Vanessa Cropley, Andrew Zalesky, Cali F Bartholomeusz

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY | SAGE PUBLICATIONS LTD | Published : 2018

DOI: 10.1177/0004867418775833

Abstract

INTRODUCTION: Schizophrenia is increasingly conceived as a disorder of brain network connectivity and organization. However, reports of network abnormalities during the early illness stage of psychosis are mixed. This study adopted a data-driven whole-brain approach to investigate functional connectivity and network architecture in a first-episode psychosis cohort relative to healthy controls and whether functional network properties changed abnormally over a 12-month period in first-episode psychosis. METHODS: Resting-state functional connectivity was performed at two time points. At baseline, 29 first-episode psychosis individuals and 30 healthy controls were assessed, and at 12 months, 14..

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University of Melbourne Researchers

Sarah Whittle Author Psychiatry

Paul Amminger Author Centre for Youth Mental Health

James Olver Author Psychiatry

Christos Pantelis Author Psychiatry

Cali Bartholomeusz Author Centre for Youth Mental Health

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Grants

Awarded by NHMRC

Funding Acknowledgements

E.P.G. was supported by the University of Melbourne and CRC for Mental Health PhD top-up scholarship. C.P. was supported by NHMRC Senior Principal Research Fellowship (628386 and 1105825). A.Z. was supported by a NHMRC Career Development Fellowship (GNT1047648) S.W. was supported by a NHMRC Career Development Fellowship (ID: 1007716).