Journal article
Antibodies to intercellular adhesion molecule 1-binding Plasmodium falciparum erythrocyte membrane protein 1-DBLβ are biomarkers of protective immunity to malaria in a cohort of young children from Papua New Guinea
SK Tessema, D Utama, O Chesnokov, AN Hodder, CS Lin, GLA Harrison, JS Jespersen, B Petersen, L Tavul, P Siba, D Kwiatkowski, T Lavstsen, DS Hansen, AV Oleinikov, I Mueller, AE Barry
Infection and Immunity | AMER SOC MICROBIOLOGY | Published : 2018
DOI: 10.1128/IAI.00485-17
Abstract
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) mediates parasite sequestration to the cerebral microvasculature via binding of DBLβ domains to intercellular adhesion molecule 1 (ICAM1) and is associated with severe cerebral malaria. In a cohort of 187 young children from Papua New Guinea (PNG), we examined baseline levels of antibody to the ICAM1-binding PfEMP1 domain, DBLβ3 PF11_0521 , in comparison to four control antigens, including NTS-DBLα and CIDR1 domains from another group A variant and a group B/C variant. Antibody levels for the group A antigens were strongly associated with age and exposure. Antibody responses to DBLβ3 PF11_0521 were associated with a 37% reduced ri..
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Awarded by National Institutes of Health
Funding Acknowledgements
This research was supported by the National Health and Medical Research Council of Australia (NHMRC grant numbers GNT1005653 and GNT1027109 to A.E.B.) and the Danish Council for Independent Research (DFF-4004-00624B). Production of DBL beta 3<INF>PF11_0521</INF> protein was supported by a U.S. National Institutes of Health grant R01AI092120 to A.V.O. I.M. is supported by an NHMRC Senior Research Fellowship. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.