Journal article

Antibodies to Intercellular Adhesion Molecule 1-Binding Plasmodium falciparum Erythrocyte Membrane Protein 1-DBL beta Are Biomarkers of Protective Immunity to Malaria in a Cohort of Young Children from Papua New Guinea

Sofonias K Tessem, Digjaya Utama, Olga Chesnokov, Anthony N Hodder, Clara S Lin, GL Abby Harrison, Jakob S Jespersen, Bent Petersen, Livingstone Tavul, Peter Siba, Dominic Kwiatkowski, Thomas Lavstsen, Diana S Hansen, Andrew Oleinikov, Ivo Mueller, Alyssa E Barry

INFECTION AND IMMUNITY | AMER SOC MICROBIOLOGY | Published : 2018

Abstract

Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) mediates parasite sequestration to the cerebral microvasculature via binding of DBLβ domains to intercellular adhesion molecule 1 (ICAM1) and is associated with severe cerebral malaria. In a cohort of 187 young children from Papua New Guinea (PNG), we examined baseline levels of antibody to the ICAM1-binding PfEMP1 domain, DBLβ3PF11_0521, in comparison to four control antigens, including NTS-DBLα and CIDR1 domains from another group A variant and a group B/C variant. Antibody levels for the group A antigens were strongly associated with age and exposure. Antibody responses to DBLβ3PF11_0521 were associated with a 37% reduced risk ..

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by Danish Council for Independent Research


Awarded by U.S. National Institutes of Health


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Funding Acknowledgements

This research was supported by the National Health and Medical Research Council of Australia (NHMRC grant numbers GNT1005653 and GNT1027109 to A.E.B.) and the Danish Council for Independent Research (DFF-4004-00624B). Production of DBL beta 3<INF>PF11_0521</INF> protein was supported by a U.S. National Institutes of Health grant R01AI092120 to A.V.O. I.M. is supported by an NHMRC Senior Research Fellowship. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.