Journal article
The impact of rotavirus vaccines on genotype diversity: A comprehensive analysis of 2 decades of australian surveillance data
S Roczo-Farkas, CD Kirkwood, D Cowley, GL Barnes, RF Bishop, N Bogdanovic-Sakran, K Boniface, CM Donato, JE Bines
Journal of Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2018
Abstract
Background Introduction of rotavirus vaccines into national immunization programs (NIPs) could result in strain selection due to vaccine-induced selective pressure. This study describes the distribution and diversity of rotavirus genotypes before and after rotavirus vaccine introduction into the Australian NIP. State-based vaccine selection facilitated a unique comparison of diversity in RotaTeq and Rotarix vaccine states. Methods From 1995 to 2015, the Australian Rotavirus Surveillance Program conducted genotypic analysis on 13051 rotavirus-positive samples from children <5 years of age, hospitalized with acute gastroenteritis. Rotavirus G and P genotypes were determined using serological a..
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Awarded by GlaxoSmithKline
Funding Acknowledgements
The Australian Rotavirus Surveillance Program is supported by research grants from the vaccine companies Commonwealth Serum Laboratories (CSL) and GlaxoSmithKline (ID116120), as well as the Australian Government Department of Health (RFQ1-2015 ARSP). The Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Support program. C. M. D. is supported through the Australian National Health and Medical Research Council with an Early Career Fellowship (1113269).