Journal article
Determining the pneumococcal conjugate vaccine coverage required for indirect protection against vaccine-type pneumococcal carriage in low and middle-income countries: A protocol for a prospective observational study
J Chan, CD Nguyen, JYR Lai, EM Dunne, R Andrews, CC Blyth, S Datta, K Fox, R Ford, J Hinds, S La Vincente, D Lehmann, R Lim, T Mungun, PN Newton, R Phetsouvanh, WS Pomat, A Xeuatvongsa, C Von Mollendorf, DAB Dance Show all
BMJ Open | BMJ PUBLISHING GROUP | Published : 2018
Abstract
Introduction Pneumococcal conjugate vaccines (PCVs) prevent disease through both direct protection of vaccinated individuals and indirect protection of unvaccinated individuals by reducing nasopharyngeal (NP) carriage and transmission of vaccine-type (VT) pneumococci. While the indirect effects of PCV vaccination are well described, the PCV coverage required to achieve the indirect effects is unknown. We will investigate the relationship between PCV coverage and VT carriage among undervaccinated children using hospital-based NP pneumococcal carriage surveillance at three sites in Asia and the Pacific. Methods and analysis We are recruiting cases, defined as children aged 2-59 months admitted..
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Awarded by Ministerio de Sanidad, Consumo y Bienestar Social
Funding Acknowledgements
This work is supported by the Bill & Melinda Gates Foundation grant number (OPP1115490). JC is completing a PhD at The University of Melbourne, funded by an Australian Government Research Training Program scholarship.