Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P-2 position of PEXEL peptidomimetics
William Nguyen, Anthony N Hodder, Richard Bestel de Lezongard, Peter E Czabotar, Kate E Jarman, Matthew T O'Neill, Jennifer K Thompson, Helene Jousset Sabroux, Alan F Cowman, Justin A Boddey, Brad E Sleebs
European Journal of Medicinal Chemistry | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | Published : 2018
Awarded by National Health and Medical Research Council of Australia
Awarded by CASS Foundation Science and Medicine Grant
Awarded by NHMRC Research Fellows
This work was funded by the National Health and Medical Research Council of Australia (Development Grant 1113712 to B.E.S. Project Grant 1092789 and Program Grant 1092789 to A.F.C.), a CASS Foundation Science and Medicine Grant SM/15/6430 to J.A.B., the Australian Cancer Research Foundation, the Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS. A.F.C. is a Howard Hughes International Scholar. P.E.C and J.A.B are NHMRC Research Fellows (1079700 and 1123727, respectively). X-ray diffraction data was collected on the MX2 beamline at the Australian Synchrotron and made use of the ACRF Detector.