Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P-2 position of PEXEL peptidomimetics

William Nguyen; Anthony N Hodder; Richard Bestel de Lezongard; Peter E Czabotar; Kate E Jarman; Matthew T O'Neill; Jennifer K Thompson; Helene Jousset Sabroux; Alan F Cowman; Justin A Boddey; Brad E Sleebs

Journal article

Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P-2 position of PEXEL peptidomimetics

William Nguyen, Anthony N Hodder, Richard Bestel de Lezongard, Peter E Czabotar, Kate E Jarman, Matthew T O'Neill, Jennifer K Thompson, Helene Jousset Sabroux, Alan F Cowman, Justin A Boddey, Brad E Sleebs

European Journal of Medicinal Chemistry | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | Published : 2018

DOI: 10.1016/j.ejmech.2018.05.022

University of Melbourne Researchers

Peter Czabotar Author Medical Biology (W.E.H.I.)

Anthony Hodder Author Medical Biology (W.E.H.I.)

Helene Jousset Sabroux Author Medical Biology (W.E.H.I.)

Alan Cowman Author Medical Biology (W.E.H.I.)

William Nguyen Author Medical Biology (W.E.H.I.)

Grants

Awarded by National Health and Medical Research Council of Australia

Awarded by CASS Foundation Science and Medicine Grant

Awarded by NHMRC Research Fellows

Funding Acknowledgements

This work was funded by the National Health and Medical Research Council of Australia (Development Grant 1113712 to B.E.S. Project Grant 1092789 and Program Grant 1092789 to A.F.C.), a CASS Foundation Science and Medicine Grant SM/15/6430 to J.A.B., the Australian Cancer Research Foundation, the Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS. A.F.C. is a Howard Hughes International Scholar. P.E.C and J.A.B are NHMRC Research Fellows (1079700 and 1123727, respectively). X-ray diffraction data was collected on the MX2 beamline at the Australian Synchrotron and made use of the ACRF Detector.