Journal article

Predicting the Presence of Oral Squamous Cell Carcinoma Using Commonly Dysregulated MicroRNA in Oral Swirls

Tami Yap, Kendrick Koo, Lesley Cheng, Laura J Vella, Andrew F Hill, Eric Reynolds, Alf Nastri, Nicola Cirillo, Christine Seers, Michael McCullough

CANCER PREVENTION RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2018

Abstract

Oral swirls are a noninvasive, rapidly collected source of salivary microRNA (miRNA) potentially useful in the early detection of disease states, particularly oral squamous cell carcinoma (OSCC). The aim of this study was to predict the presence of OSCC using a panel of OSCC-related dysregulated miRNA found in oral swirls, identified jointly in data from formalin-fixed paraffin-embedded (FFPE) and fresh-frozen specimens. Next-generation sequencing (NGS) was used to determine miRNA fold changes in FFPE OSCC specimens relative to histologically normal epithelium. These data were placed with NGS of fresh-frozen tissue data of The Cancer Genome Atlas database to select a panel of commonly dysreg..

View full abstract