Journal article

Neurocognitive dysfunction in subjects at clinical high risk for psychosis: A meta-analysis

Wei Zheng, Qing-E Zhang, Dong-Bin Cai, Chee H Ng, Gabor S Ungvari, Yu-Ping Ning, Yu-Tao Xiang

JOURNAL OF PSYCHIATRIC RESEARCH | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2018

Abstract

Findings of neurocognitive dysfunction in subjects at Clinical High Risk for Psychosis (CHR-P) have been controversial. This meta-analysis systematically examined studies of neurocognitive functions using the MATRICS Consensus Cognitive Battery (MCCB) in CHR-P. An independent literature search of both English and Chinese databases was conducted by two reviewers. Standardized mean difference (SMD) was calculated using a random effects model to evaluate the effect size of the meta-analytic results. Six case-control studies (n = 396) comparing neurocognitive functions between CHR-P subjects (n = 197) and healthy controls (n = 199) using the MCCB were identified; 4 (66.7%) studies were rated as ..

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University of Melbourne Researchers