Journal article

Comparative Analysis of Markers of Mass Effect after Ischemic Stroke

Ann-Christin Ostwaldt, Thomas WK Battey, Hannah J Irvine, Bruce CV Campbell, Stephen M Davis, Geoffrey A Donnan, W Taylor Kimberly

JOURNAL OF NEUROIMAGING | WILEY | Published : 2018

Abstract

BACKGROUND AND PURPOSE: Midline shift determined on magnetic resonance imaging (MRI) or computed tomography (CT) images is a well-validated marker of mass effect after large hemispheric infarction and associated with mortality. In this study, we targeted a population with moderately sized strokes. We compared midline shift to other imaging markers and determined their ability to predict long-term outcome. METHODS: MRI scans were studied from the Echoplanar Imaging Thrombolysis Evaluation Trial (EPITHET) cohort. Midline shift, acute stroke lesion volume, lesional swelling volume, change in ipsilateral hemisphere volume, the ratio of ipsilateral to contralateral hemisphere volume, and the redu..

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Grants

Awarded by National Institutes of Health


Awarded by American Heart Association


Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE


Funding Acknowledgements

The original funding for the EPITHET trial was from the National Health and Medical Research Council, Australia. The analysis performed for this study was funded in part by the National Institutes of Health, NIH/NINDS K23NS076597, R01 NS099209, and American Heart Association, AHA 14GRNT19060044. The authors report no conflicts of interest.