Journal article

High Risk of Plasmodium vivax Malaria Following Splenectomy in Papua, Indonesia

Steven Kho, Benediktus Andries, Jeanne R Poespoprodjo, Robert J Commons, Putu AI Shanti, Enny Kenangalem, Nicholas M Douglas, Julie A Simpson, Paulus Sugiarto, Nicholas M Anstey, Ric N Price

Clinical Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2019

Abstract

Background: Splenectomy increases the risk of severe and fatal infections; however, the risk of Plasmodium vivax malaria is unknown. We quantified the Plasmodium species-specific risks of malaria and other outcomes following splenectomy in patients attending a hospital in Papua, Indonesia. Methods: Records of all patients attending Mitra-Masyarakat Hospital 2004-2013 were reviewed, identifying those who underwent splenectomy. Subsequent risks of specific clinical outcomes within 12 months for splenectomized patients were compared to nonsplenectomized patients from their first recorded hospital admission. In addition, patients splenectomized for trauma 2015-2016 were followed prospectively fo..

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Grants

Awarded by Wellcome Trust


Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by Wellcome Trust Training fellowship in Tropical Medicine


Funding Acknowledgements

This work was supported by the Wellcome Trust (Senior Fellowship in Clinical Science to RNP, grant 200909) and the Australian National Health and Medical Research Council (NHMRC) (program grant 1037304 awarded to R. N. P. and N. M. A., and Practitioner and Research Fellowships [1042072 and 1135820] to N. M. A.). S. K. was supported by an Australian Government Postgraduate Award scholarship. J. R. P. was funded by a Wellcome Trust Training fellowship in Tropical Medicine (grant 099875). J. A. S. is supported by a NHMRC Research Fellowship. R. J. C. was supported by a postgraduate NHMRC scholarship and a RACP NHMRC Kincaid-Smith scholarship. The Timika Research Facility and Papuan Community Health Foundation are supported by the Australian Department of Foreign Affairs and Trade.