Deterioration of Cortical Bone Microarchitecture: Critical Component of Renal Osteodystrophy Evaluation
Ashish K Sharma, Nigel D Toussaint, Rosemary Masterson, Stephen G Hoit, Chamith S Rajapakse, Peter R Ebeling, Sindhu T Mohanty, Paul Baldock, Grahame J Elder
AMERICAN JOURNAL OF NEPHROLOGY | KARGER | Published : 2018
BACKGROUND: Cortical bone is a significant determinant of bone strength and its deterioration contributes to bone fragility. Thin cortices and increased cortical porosity have been noted in patients with chronic kidney disease (CKD), but the "Turnover Mineralization Volume" classification of renal osteodystrophy does not emphasize cortical bone as a key parameter. We aimed to assess trabecular and cortical bone microarchitecture by histomorphometry and micro-CT in patients with CKD G5 and 5D (dialysis). METHODS: Transiliac bone biopsies were performed in 14 patients undergoing kidney transplantation (n = 12) and parathyroidectomy (n = 2). Structural parameters were analysed by histomorphomet..View full abstract
We acknowledge and thank Amgen Australia for providing an unrestricted educational grant that partly funded this study.