Journal article
Interactive Associations of Vascular Risk and beta-Amyloid Burden With Cognitive Decline in Clinically Normal Elderly Individuals Findings From the Harvard Aging Brain Study
Jennifer S Rabin, Aaron P Schultz, Trey Hedden, Anand Viswanathan, Gad A Marshall, Emily Kilpatrick, Hannah Klein, Rachel F Buckley, Hyun-Sik Yang, Michael Properzi, Vaishnavi Rao, Dylan R Kirn, Kathryn V Papp, Dorene M Rentz, Keith A Johnson, Reisa A Sperling, Jasmeer P Chhatwal
JAMA NEUROLOGY | AMER MEDICAL ASSOC | Published : 2018
Abstract
Importance: Identifying asymptomatic individuals at high risk of impending cognitive decline because of Alzheimer disease is crucial for successful prevention of dementia. Vascular risk and β-amyloid (Aβ) pathology commonly co-occur in older adults and are significant causes of cognitive impairment. Objective: To determine whether vascular risk and Aβ burden act additively or synergistically to promote cognitive decline in clinically normal older adults; and, secondarily, to evaluate the unique influence of vascular risk on prospective cognitive decline beyond that of commonly used imaging biomarkers, including Aβ burden, hippocampal volume, fludeoxyglucose F18-labeled (FDG) positron emissio..
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Awarded by National Institutes of Health
Awarded by National Health and Medical Research Council Dementia Research Fellowship
Awarded by Center for Functional Neuroimaging Technologies
Awarded by High-End Instrumentation Grant Program
Awarded by NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING
Awarded by NATIONAL INSTITUTE ON AGING
Funding Acknowledgements
This work was supported by the National Institutes of Health via grants P01 AG036694 (Drs Sperling and Johnson); P50 AG005134 (Dr Sperling, Johnson, Viswanathan, and Hedden); K24 AG035007 (Dr Sperling); R01 AG053509 (Dr Hedden); K01 AG040197 (Dr Hedden); R01 AG047975, K23 AG028726, R01 AG026484, and K23 AG02872605 (Dr Viswanathan); K23 AG053422 (Dr. Papp); and K23 AG049087 (Dr Chhatwal). Additional support was provided by the Canadian Institutes of Health Research Postdoctoral Fellowship (Dr Rabin), the National Health and Medical Research Council Dementia Research Fellowship (grant APP1105576; Dr Buckley). This research was carried out in part at the Athinoula A. Martinos Center for Biomedical Imaging at the Massachusetts General Hospital, using resources provided by the Center for Functional Neuroimaging Technologies (grant P41EB015896), a P41 Biotechnology Resource Grant supported by the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health. This work also involved the use of instrumentation supported by the National Institutes of Health Shared Instrumentation Grant Program and/or High-End Instrumentation Grant Program (grants S10RR021110, S10RR023401, and S10RR023043).