Global conformational changes in IgG-Fc upon mutation of the FcRn-binding site are not associated with altered antibody-dependent effector functions
Ingrid JG Burvenich, William Farrugia, Zhanqi Liu, Dahna Makris, Dylan King, Benjamin Gloria, Angelo Perani, Laura C Allan, Andrew M Scott, Paul A Ramsland
Biochemical Journal | PORTLAND PRESS LTD | Published : 2018
Awarded by NHMRC
This research was supported by NHMRC Project Grants 542512 and 1030469, NHMRC Program grants 487922 and 1092788, NHMRC Practitioner Fellowship 1084178 (A.M.S.) and in part by Ludwig Cancer Research, and the Operational Infrastructure Support Program provided by the Victorian Government. This research was partly undertaken at the MX1 and MX2 beamlines at the Australian Synchrotron, Victoria, Australia.