Journal article
Delayed diagnosis and complications of predominantly antibody deficiencies in a cohort of Australian adults
CA Slade, JJ Bosco, TB Giang, E Kruse, RG Stirling, PU Cameron, F Hore-Lacy, MF Sutherland, SL Barnes, S Holdsworth, S Ojaimi, GA Unglik, J De Luca, M Patel, J McComish, K Spriggs, Y Tran, P Auyeung, K Nicholls, RE O'Hehir Show all
Frontiers in Immunology | FRONTIERS MEDIA SA | Published : 2018
Abstract
Background: Predominantly antibody deficiencies (PADs) are the most common type of primary immunodeficiency in adults. PADs frequently pass undetected leading to delayed diagnosis, delayed treatment, and the potential for end-organ damage including bronchiectasis. In addition, PADs are frequently accompanied by comorbid autoimmune disease, and an increased risk of malignancy. Objectives: To characterize the diagnostic and clinical features of adult PAD patients in Victoria, Australia. Methods: We identified adult patients receiving, or having previously received immunoglobulin replacement therapy for a PAD at four hospitals in metropolitan Melbourne, and retrospectively characterized their c..
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Awarded by National Science Foundation
Funding Acknowledgements
The authors acknowledge the Melbourne Genomics Health Alliance, supported by the Victorian Government and Alliance members, the Australian National Health and Medical Research Council (NHMRC, Project Grant 1127198 for VB; Postgraduate Scholarship 1075666 for CS; Senior Research Fellowship 1117687 for MZ), The Jeffrey Modell Foundation, and Independent Research Institutes Infrastructure Support Scheme Grant 361646 for fellowship and grant funding support. VB also receives support from the Victorian State Government Operational Infrastructure Scheme and Australian Government NHMRC IRIISS, Holmes Grant Charitable Trust, Rae Grant, Bloody Long Way (BLW), and Walter and Eliza Hall Institute Innovation Grant.