Journal article
N-cadherin identifies human endometrial epithelial progenitor cells by in vitro stem cell assays
HPT Nguyen, L Xiao, JA Deane, KS Tan, FL Cousins, H Masuda, CN Sprung, A Rosamilia, CE Gargett
Human Reproduction | OXFORD UNIV PRESS | Published : 2017
Abstract
STUDY QUESTION: Is there a specific surface marker that identifies human endometrial epithelial progenitor cells with adult stem cell activity using in vitro assays? SUMMARY ANSWER: N-cadherin isolates clonogenic, self-renewing human endometrial epithelial progenitor cells with high proliferative potential that differentiate into cytokeratin+ gland-like structures in vitro and identifies their location in some cells of gland profiles predominantly in basalis endometrium adjacent to the myometrium. WHAT IS KNOWN ALREADY: Human endometrium contains a small population of clonogenic, self-renewing epithelial cells with high proliferative potential that differentiate into large gland-like structu..
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Awarded by Texas Water Development Board
Funding Acknowledgements
Cancer Council Victoria grant 491079 (C.E.G.) and Australian National Health and Medical Research Council grants 1021127 (C.E.G.), 1085435 (C.E.G., J.A.D.), 145780 and 288713 (C.N.S.), RD Wright Career Development Award 465121 (C.E.G.), Senior Research Fellowship 1042298 (C.E.G.), the Victorian Government's Operational Infrastructure Support and an Australian Postgraduate Award (H.P.T.N.), and China Council Scholarship (L.X.).