Journal article
Evidence of CD4 T cell-mediated immune pressure on the Hepatitis C virus genome
M Lucas, P Deshpande, I James, A Rauch, K Pfafferott, E Gaylard, S Merani, A Plauzolles, A Lucas, W McDonnell, S Kalams, M Pilkinton, C Chastain, L Barnett, A Prosser, S Mallal, K Fitzmaurice, H Drummer, MA Ansari, V Pedergnana Show all
Scientific Reports | NATURE PORTFOLIO | Published : 2018
Abstract
Hepatitis C virus (HCV)-specific T cell responses are critical for immune control of infection. Viral adaptation to these responses, via mutations within regions of the virus targeted by CD8+ T cells, is associated with viral persistence. However, identifying viral adaptation to HCV-specific CD4+ T cell responses has been difficult although key to understanding anti-HCV immunity. In this context, HCV sequence and host genotype from a single source HCV genotype 1B cohort (n = 63) were analyzed to identify viral changes associated with specific human leucocyte antigen (HLA) class II alleles, as these variable host molecules determine the set of viral peptides presented to CD4+ T cells. Eight s..
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Awarded by Raine Medical Research Foundation
Funding Acknowledgements
The authors wish to thank Drs Mark Watson and Susan Herrmann from the Institute for Immunology and Infectious Diseases at Murdoch University, Australia. We also thank Professor Timothy Sterling, Sally Bebawy, Megan Turner, Chike Abana, Rama Gangula and Cindy Hager from the Department of Medicine, Division of Infectious Diseases at Vanderbilt University Medical Centre, USA. This study was, in part, funded by the McCusker Research Foundation, Raine Medical Research Foundation, Australian Centre for HIV and Hepatitis Virology Research and the NIH-funded Tennessee Center for AIDS Research (P30 AI110527). This study was also partly financed within the framework of the Swiss HIV Cohort Study, supported by the Swiss National Science Foundation (grant # 148522), by SHCS project # 430 and by the SHCS research foundation. The data are gathered by the Five Swiss University Hospitals, two Cantonal Hospitals, 15 affiliated hospitals and 36 private physicians (listed in http://www.shcs.ch/180-health-care-providers). Members of the Swiss HIV Cohort Study: Aubert V, Battegay M, Bernasconi E, Boni J, Braun DL, Bucher HC, Burton-Jeangros C, Calmy A, Cavassini M, Dollenmaier G, Egger M, Elzi L, Fehr J, Fellay J, Furrer H (Chairman of the Clinical and Laboratory Committee), Fux CA, Gorgievski M, Gunthard H (President of the SHCS), Haerry D (deputy of "Positive Council"), Hasse B, Hirsch HH, Hoffmann M, Hosli I, Kahlert C, Kaiser L, Keiser O, Klimkait T, Kouyos R, Kovari H, Ledergerber B, Martinetti G, Martinez de Tejada B, Marzolini C, Metzner K, Muller N, Nadal D, Nicca D, Pantaleo G, Rauch A (Chairman of the Scientific Board), Regenass S, Rudin C (Chairman of the Mother & Child Substudy), Schoni-Affolter F (Head of Data Centre), Schmid P, Speck R, Stockle M, Tarr P, Trkola A, Vernazza P, Weber R, Yerly S. EB is funded by the Oxford NIHR BRC and also the Medical Research Council as a Senior Clinical Fellow. Data from the Boson cohort was provided by the STOP-HCV Consortium (funded by the Medical Research Council, UK: MR/K01532X/1).