Journal article
Group a Streptococcus M1T1 intracellular infection of primary tonsil epithelial cells dampens levels of secreted IL-8 through the action of SpyCEP
AT Soderholm, TC Barnett, O Korn, T Rivera-Hernandez, LM Seymour, BL Schulz, V Nizet, CA Wells, MJ Sweet, MJ Walker
Frontiers in Cellular and Infection Microbiology | FRONTIERS MEDIA SA | Published : 2018
Abstract
Streptococcus pyogenes (Group A Streptococcus; GAS) commonly causes pharyngitis in children and adults, with severe invasive disease and immune sequelae being an infrequent consequence. The ability of GAS to invade the host and establish infection likely involves subversion of host immune defenses. However, the signaling pathways and innate immune responses of epithelial cells to GAS are not well-understood. In this study, we utilized RNAseq to characterize the inflammatory responses of primary human tonsil epithelial (TEpi) cells to infection with the laboratory-adapted M6 strain JRS4 and the M1T1 clinical isolate 5448. Both strains induced the expression of genes encoding a wide range of i..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
AS is supported by a Research Training Program scholarship from the Australian Government. TB is supported by a Career Development Fellowship from the NHMRC-funded Improving Health Outcomes in the Tropical North: A multidisciplinary collaboration (Hot North; APP1131932). MS is supported by an NHMRC Senior Research Fellowship (APP1107914). MW is supported by an NHMRC Principal Research Fellowship (APP1102621). The authors acknowledge support from the NHMRC research granting system.