Journal article
Transferable Matrixes Produced from Decellularized Extracellular Matrix Promote Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells and Facilitate Scale-Up
GD Kusuma, MC Yang, SP Brennecke, AJ O'Connor, B Kalionis, DE Heath
ACS Biomaterials Science and Engineering | AMER CHEMICAL SOC | Published : 2018
Abstract
Decellularized extracellular matrixes (dECM) derived from mesenchymal stem cell (MSC) cultures have recently emerged as cell culture substrates that improve the proliferation, differentiation, and maintenance of MSC phenotype during ex vivo expansion. These biomaterials have considerable potential in the fields of stem cell biology, tissue engineering, and regenerative medicine. Processing the dECMs into concentrated solutions of biomolecules that enable the useful properties of the native dECM to be transferred to a new surface via a simple adsorption step would greatly increase the usefulness and impact of this technology. The development of such solutions, hereafter referred to as transfe..
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Funding Acknowledgements
The authors thank the research midwives at Royal Women's Hospital, Sue Duggan and Moira Stewart, for their collection and consenting of patient samples. The authors acknowledge funding support through the University of Melbourne Early Career Researcher Scheme, the Selby Foundation, Equity Trustees, and the Therapeutic Technologies Hallmark Research Initiative.