Journal article
Risk of Progression of Nonalbuminuric CKD to End-Stage Kidney Disease in People With Diabetes: The CRIC (Chronic Renal Insufficiency Cohort) Study
DN Koye, DJ Magliano, CM Reid, C Jepson, HI Feldman, WH Herman, JE Shaw
American Journal of Kidney Diseases | W B SAUNDERS CO-ELSEVIER INC | Published : 2018
Abstract
Background: Reduced glomerular filtration rate (GFR) in the absence of albuminuria is a common manifestation of chronic kidney disease (CKD) in diabetes. However, the frequency with which it progresses to end-stage kidney disease (ESKD) is unknown. Study Design: Multicenter prospective cohort study. Setting & Participants: We included 1,908 participants with diabetes and reduced GFR enrolled in the Chronic Renal Insufficiency Cohort (CRIC) Study in the United States. Predictors: Urinary albumin and protein excretion. Outcomes: Incident ESKD, CKD progression (ESKD or ≥50% reduction in estimated GFR [eGFR] from baseline), and annual rate of decline in kidney function. Measurements: ESKD was as..
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Awarded by National Institute of Diabetes and Digestive and Kidney Diseases
Funding Acknowledgements
The CRIC Study was conducted by the CRIC Study Investigators and supported by the NIDDK. Data from the CRIC Study reported here were supplied by the NIDDK Central Repositories. Mr Koye is supported by a Monash University Postgraduate Research Scholarship and a Baker IDI Bright Sparks Scholarship. Drs Magliano, Reid, and Shaw are supported by the National Health and Medical Research Council Senior Research Fellowships. This work is partially supported by the Victorian Government's Operational Infrastructure Support Program.