Conference Proceedings

Female Reproductive and Hormonal Factors and Incidence of Primary Total Knee Arthroplasty Due to Osteoarthritis

Sultana Monira Hussain, Yuanyuan Wang, Graham G Giles, Stephen Graves, Anita Wluka, Flavia M Cicuttini



OBJECTIVE: To examine the associations of female reproductive and hormonal factors with incidence of total knee arthroplasty (TKA) for osteoarthritis (OA), and to determine whether the associations differ according to overweight/obesity status. METHODS: This study included 22,289 women in the Melbourne Collaborative Cohort Study. Data on age at menarche, pregnancy, parity, years of menstruation, oral contraceptive (OC) use, menopausal status, and hormone replacement therapy (HRT) were collected in 1990-1994. Incidence of TKA during 2001-2013 was determined by linking cohort records to the Australian Orthopaedic Association National Joint Replacement Registry. All analyses were adjusted for a..

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Awarded by Australian National Health and Medical Research Council (NHMRC)

Awarded by NHMRC Early Career Fellowship

Awarded by NHMRC Career Development Fellowships

Funding Acknowledgements

Supported by the Australian National Health and Medical Research Council (NHMRC) (grants 209057, 251553, and 504711) and Cancer Council Victoria. Recruitment of the Melbourne Collaborative Cohort Study was supported by VicHealth and Cancer Council Victoria. Dr. Hussain is recipient of an NHMRC Early Career Fellowship (grant 1142198). Drs. Wang and Wluka are recipients of NHMRC Career Development Fellowships (Clinical Level 1 grant 1065464 and Clinical Level 2 grant 1063574, respectively).