Journal article

Heart rate variability in epilepsy: A potential biomarker of sudden unexpected death in epilepsy risk

Kenneth A Myers, Luis E Bello-Espinosa, Joseph D Symonds, Sameer M Zuberi, Robin Clegg, Lynette G Sadleir, Jeffrey Buchhalter, Ingrid E Scheffer

EPILEPSIA | WILEY | Published : 2018

Abstract

OBJECTIVE: Sudden unexpected death in epilepsy (SUDEP) is a tragic and devastating event for which the underlying pathophysiology remains poorly understood; this study investigated whether abnormalities in heart rate variability (HRV) are linked to SUDEP in patients with epilepsy due to mutations in sodium channel (SCN) genes. METHODS: We retrospectively evaluated HRV in epilepsy patients using electroencephalographic studies to study the potential contribution of autonomic dysregulation to SUDEP risk. We extracted HRV data, in wakefulness and sleep, from 80 patients with drug-resistant epilepsy, including 40 patients with mutations in SCN genes and 40 control patients with non-SCN drug-resi..

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University of Melbourne Researchers

Grants

Awarded by Citizens United for Research in Epilepsy


Awarded by National Health and Medical Research Council


Awarded by Health Research Council of New Zealand


Funding Acknowledgements

Alberta Children's Hospital Research Institute; Citizens United for Research in Epilepsy, Grant/Award Number: 439534; National Health and Medical Research Council, Grant/Award Number: 1091593, 1104831; Epilepsy Research UK; Dravet Syndrome UK; Glasgow Children's Hospital Charity; UCB Pharma; Health Research Council of New Zealand, Grant/Award Number: 15/070; Cure Kids, and the Ted and Mollie Carr Endowment Trust; NIH; March of Dimes; Weizmann Institute; US Department of Defense, and Perpetual Charitable Trustees