Journal article
Heart rate variability in epilepsy: A potential biomarker of sudden unexpected death in epilepsy risk
Kenneth A Myers, Luis E Bello-Espinosa, Joseph D Symonds, Sameer M Zuberi, Robin Clegg, Lynette G Sadleir, Jeffrey Buchhalter, Ingrid E Scheffer
EPILEPSIA | WILEY | Published : 2018
DOI: 10.1111/epi.14438
Abstract
OBJECTIVE: Sudden unexpected death in epilepsy (SUDEP) is a tragic and devastating event for which the underlying pathophysiology remains poorly understood; this study investigated whether abnormalities in heart rate variability (HRV) are linked to SUDEP in patients with epilepsy due to mutations in sodium channel (SCN) genes. METHODS: We retrospectively evaluated HRV in epilepsy patients using electroencephalographic studies to study the potential contribution of autonomic dysregulation to SUDEP risk. We extracted HRV data, in wakefulness and sleep, from 80 patients with drug-resistant epilepsy, including 40 patients with mutations in SCN genes and 40 control patients with non-SCN drug-resi..
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Grants
Awarded by Citizens United for Research in Epilepsy
Awarded by National Health and Medical Research Council
Awarded by Health Research Council of New Zealand
Funding Acknowledgements
Alberta Children's Hospital Research Institute; Citizens United for Research in Epilepsy, Grant/Award Number: 439534; National Health and Medical Research Council, Grant/Award Number: 1091593, 1104831; Epilepsy Research UK; Dravet Syndrome UK; Glasgow Children's Hospital Charity; UCB Pharma; Health Research Council of New Zealand, Grant/Award Number: 15/070; Cure Kids, and the Ted and Mollie Carr Endowment Trust; NIH; March of Dimes; Weizmann Institute; US Department of Defense, and Perpetual Charitable Trustees