Diabetes-Specific Formulae Versus Standard Formulae as Enteral Nutrition to Treat Hyperglycemia in Critically Ill Patients: Protocol for a Randomized Controlled Feasibility Trial
Ra'eesa Doola, Alwyn S Todd, Josephine M Forbes, Adam M Deane, Jeffrey J Presneill, David J Sturgess
JMIR RESEARCH PROTOCOLS | JMIR PUBLICATIONS, INC | Published : 2018
BACKGROUND: During critical illness, hyperglycemia is prevalent and is associated with adverse outcomes. While treating hyperglycemia with insulin reduces morbidity and mortality, it increases glycemic variability and hypoglycemia risk, both of which have been associated with an increase in mortality. Therefore, other interventions which improve glycemic control, without these complications should be explored. Nutrition forms part of standard care, but the carbohydrate load of these formulations has the potential to exacerbate hyperglycemia. Specific diabetic-formulae with a lesser proportion of carbohydrate are available, and these formulae are postulated to limit glycemic excursions and re..View full abstract
This study has been funded through Mater Research by the Mater Foundation through two research grants - the first for the primary study and the second for the biomarker analysis. RD is a recipient of the Mater Foundation Betty McGrath Fellowship which has provided financial support to undertake her PhD.