Signal quality of simultaneously recorded endovascular, subdural and epidural signals are comparable

Sam E John; Nicholas L Opie; Yan T Wong; Gil S Rind; Stephen M Ronayne; Giulia Gerboni; Sebastien H Bauquier; Terence J O'Brien; Clive N May; David B Grayden; Thomas J Oxley

Journal article

Signal quality of simultaneously recorded endovascular, subdural and epidural signals are comparable

Sam E John, Nicholas L Opie, Yan T Wong, Gil S Rind, Stephen M Ronayne, Giulia Gerboni, Sebastien H Bauquier, Terence J O'Brien, Clive N May, David B Grayden, Thomas J Oxley

SCIENTIFIC REPORTS | NATURE PUBLISHING GROUP | Published : 2018

DOI: 10.1038/s41598-018-26457-7

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Abstract

Recent work has demonstrated the feasibility of minimally-invasive implantation of electrodes into a cortical blood vessel. However, the effect of the dura and blood vessel on recording signal quality is not understood and may be a critical factor impacting implementation of a closed-loop endovascular neuromodulation system. The present work compares the performance and recording signal quality of a minimally-invasive endovascular neural interface with conventional subdural and epidural interfaces. We compared bandwidth, signal-to-noise ratio, and spatial resolution of recorded cortical signals using subdural, epidural and endovascular arrays four weeks after implantation in sheep. We show t..

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University of Melbourne Researchers

Nicholas Opie Author Medicine - Royal Melbourne Hospital

Thomas Oxley Author Medicine - Royal Melbourne Hospital

Sam John Author Biomedical Engineering

Clive May Author Biochemistry and Pharmacology

Stephen Ronayne Author Medicine - Royal Melbourne Hospital

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)

Awarded by US Defense Advanced Research Projects Agency (DARPA) Microsystems Technology Office

Awarded by Office of Naval Research (ONR)

Funding Acknowledgements

We thank Covidien (Medtronic) for provision of 30 Solitaire stentriever devices as a product research grant. T. Dornum, A. McDonald and T. Vale for surgical and animal handling assistance. We also acknowledge Prof. A. Burkitt, Mr. A. Meltzer, Mr. Stefan Wilson, and Mr. T. Scordas for their support and input. This work was funded by the National Health and Medical Research Council of Australia (NHMRC) Project Grant APP1062532, US Defense Advanced Research Projects Agency (DARPA) Microsystems Technology Office contract N66001-12-1- 4045; Office of Naval Research (ONR) lobal N62909-14-1-N020; Defence Health Foundation, Australia (Booster Grant); and the Victorian Government's Operational Infrastructure Support Program.