Magnetic resonance imaging based assessment of bone microstructure as a non-invasive alternative to histomorphometry in patients with chronic kidney disease
Ashish K Sharma, Nigel D Toussaint, Grahame J Elder, Rosemary Masterson, Stephen G Holt, Patricia L Robertson, Peter R Ebeling, Paul Baldock, Rhiannon C Miller, Chamith S Rajapakse
BONE | ELSEVIER SCIENCE INC | Published : 2018
BACKGROUND: Chronic kidney disease (CKD) adversely affects bone microarchitecture and increases fracture risk. Historically, bone biopsy has been the 'gold standard' for evaluating renal bone disease but is invasive and infrequently performed. High-resolution magnetic resonance imaging (MRI) quantifies bone microarchitecture noninvasively. In patients with CKD, it has not been compared with results derived from bone biopsy or with imaging using dual energy X-ray absorptiometry (DXA). METHODS: Fourteen patients with end-stage kidney disease (ESKD) underwent MRI at the distal tibia, bone mineral density (BMD) by dual energy X-ray absorptiometry (DXA; hip and spine) and transiliac bone biopsies..View full abstract
We acknowledge Amgen Australia for an unrestricted educational grant for part funding of this study.