Journal article
Low-Fouling and Biodegradable Protein-Based Particles for Thrombus Imaging
Thomas Bonnard, Anand Jayapadman, Jasmine A Putri, Jiwei Cui, Yi Ju, Catherine Carmichael, Thomas A Angelovich, Stephen H Cody, Shauna French, Karline Pascaud, Hannah A Pearce, Shweta Jagdale, Frank Caruso, Christoph E Hagemeyer
ACS NANO | AMER CHEMICAL SOC | Published : 2018
Abstract
Nanomedicine holds great promise for vascular disease diagnosis and specific therapy, yet rapid sequestration by the mononuclear phagocytic system limits the efficacy of particle-based agents. The use of low-fouling polymers, such as poly(ethylene glycol), efficiently reduces this immune recognition, but these nondegradable polymers can accumulate in the human body and may cause adverse effects after prolonged use. Thus, new particle formulations combining stealth, low immunogenicity and biocompatible features are required to enable clinical use. Here, a low-fouling particle platform is described using exclusively protein material. A recombinant protein with superior hydrophilic characterist..
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Grants
Awarded by National Health and Medical Research Council (NHMRC)
Awarded by National Heart Foundation of Australia
Awarded by NHMRC Senior Principal Research Fellowship
Awarded by Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology
Awarded by ARC under the Australian Laureate Fellowship
Awarded by People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme (FP7/2007-2013) under REA grant
Funding Acknowledgements
This work was funded by the National Health and Medical Research Council (NHMRC, Project Grant 1078118 to C.E.H.) and the National Heart Foundation of Australia (Fellowship CR11M6066 to C.E.H.). F.C. acknowledges the award of an NHMRC Senior Principal Research Fellowship (APP1135806). This research was also funded by the Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology (Project Number CE140100036) and funded by the ARC under the Australian Laureate Fellowship (F1120100030 to F.C.) scheme. T.B. has received funding from the People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme (FP7/2007-2013) under REA grant agreement no. 608765. J.C. acknowledges the Thousand Talents Plan Program of China. We thank Dr. D. Steer from the Monash Biochemical Proteomics Facility, C. Cohen and A. Shad from the Monash Histology Platform, E. Orlowski Oliver from the AMREP flow core, Dr. I. Carmichael from Monash Micro Imaging, and J. Tran for technical advice and assistance. We thank Prof. P. S. Donnelly and Dr. T. U. Connell for providing the G-PEG3-BCN compound.