Journal article
Maternal age at delivery, lung function and asthma in offspring: A population-based survey
FG Real, JA Burgess, S Villani, J Dratva, J Heinrich, C Janson, D Jarvis, J Koplin, B Leynaert, C Lodge, BN Lærum, MC Matheson, D Norbäck, ER Omenaas, SM Skulstad, J Sunyer, SC Dharmage, C Svanes
European Respiratory Journal | EUROPEAN RESPIRATORY SOC JOURNALS LTD | Published : 2018
Abstract
There is limited information about potential impact of maternal age on the respiratory health of offspring. We investigated the association of maternal age at delivery with adult offspring’s lung function, respiratory symptoms and asthma, and potential differences according to offspring sex. 10692 adults from 13 countries participating in the European Community Respiratory Health Survey (ECRHS) II responded to standardised interviews and provided lung function measurements and serum for IgE measurements at age 25–55 years. In logistic and linear multilevel mixed models we adjusted for participants’ characteristics (age, education, centre, number of older siblings) and maternal characteristic..
View full abstractGrants
Awarded by Collins Foundation
Funding Acknowledgements
This study was supported by the American Lung Association of Oregon, USA; ASL 4 Regione Piemonte, Italy; Asthma UK; Aventis, France; Azienda Ospedaliera Centro Traumatologico Ospedaliero/Centro Traumatologico Ortopedico-Istituto Clinico Ortopedico Regina Maria Adelaide, Regione Piemonte, Italy; the Basque Health Dept., Spain; the British Lung Foundation; Bundesminister fur Forschung und Technologie, Bonn, Germany; Caisse Nationale de l'Assurance Maladie des Travailleurs Salaries, France; Centre Hospitalier Universitarie (CHU) de Grenoble, France; the Collins Foundation; Comite des Maladies Respiratoires de l'Isere, France; Comite National Contre les Maladies Respiratoires et la Tuberculose, France; Consejeria de Sanidad Principado de Asturias, Spain; Consell Interdepartamental de Recerca i Innovacio Tecnologica, Barcelona, Spain (grant number 1999SGR 00241); Consiglio Nazionale delle Ricerche (grant number 381/05.93); Contrat de Plan Etat-Region Languedoc-Rousillon, France; the Dept of Health; Deutsche Forschungsgemeinschaft (grant number MA 711/4-1); Direction de la Recherche Clinique, France; Direction Generale de la Sante, France; Direction Regionale des Affaires Sanitaires et Sociales Languedoc-Roussillon, France; the Dutch Ministry of Wellbeing, Public Health and Culture, The Netherlands; Eesti Teadusfondi; Federaal Wetenschapsbeleid; Fondo de Investigaciones Santarias (FIS), Spain (grant numbers 97/0035-01, 99/0034-01 and 99/0034-02); Fonds Wetenschappelijk Onderzoek (grant number G.0402.00); Glaxo, France; Glaxo-SmithKline, Italy; Glaxo Wellcome AS, Norway Research Fund; Glaxo Wellcome spa, Italy; GSF-National Research Centre for Environment & Health, Deutsche Forschungsgemeinschaft (DFG), Germany (grant number FR 1526/1-1); Hjart-Lungfonden; Hospital General de Albacete, Spain; Hospital General Juan Ramon Jimenenz de Huelva, Spain; Icelandic Research Council; Icelandic University Hospital Fund; Institut Pneumologique d'Aquitaine, France; Italian Ministry of University and Scientific and Technological Research (MURST); Local University Funding for research 1998 & 1999, Pavia, Italy; Merck; Ministere de l'Emploi et de la Solidarite, France; Ministere de la Sante; Ministero dell'Universita e della Ricerca Scientifica e Tecnologica, Italy; Ministero Sanidad y Consumo FIS, Spain (grant number 91/0016060/00E-05E and 93/0393); Ministre delegue de la sante, France; Northwest Health Foundation; Norwegian Asthma & Allergy Association (NAAF); Norwegian Research Council (grant numbers 101422/310 and 228174/H10); Programme Hospitalier de Recherche Clinique-DRC de Grenoble 2000, France (grant number 2610); Reseau National de Sante Publique, France; Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung (grant number 4026-28099); Sociedad Espanola de Patologia Respiratoria, Public Health Service, Barcelona, Spain (grant number R01 HL62633-01); South Thames Regional Health Authority, UK; Swedish Asthma & Allergy Foundation; Swedish Cancer & Allergy Foundation; Swiss Federal Office for Education & Science; Swiss National Accident Insurance Fund (SUVA); US Department of Health, Education and Welfare (grant number 2 S07 RR05521-28); Union Chimique Belge - Pharma, France; Universita degli Studi di Verona; and Vardalstiftelsen.