Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

DM Ruderfer; S Ripke; A McQuillin; J Boocock; EA Stahl; JMW Pavlides; N Mullins; AW Charney; APS Ori; LMO Loohuis; E Domenici; A Di Florio; S Papiol; JL Kalman; V Trubetskoy; R Adolfsson; I Agartz; E Agerbo; H Akil; D Albani; M Albus; M Alda; M Alexander; N Alliey-Rodriguez; TD Als; F Amin; A Anjorin; MJ Arranz; S Awasthi; SA Bacanu; JA Badner; M Baekvad-Hansen; S Bakker; G Band; JD Barchas; I Barroso; N Bass; M Bauer; BT Baune; M Begemann; C Bellenguez; RA Belliveau; F Bellivier; S Bender; J Bene; SE Bergen; WH Berrettini; E Bevilacqua; JM Biernacka; TB Bigdeli; DW Black; H Blackburn; JM Blackwell; DHR Blackwood; CB Pedersen; M Boehnke; M Boks; AD Borglum; E Bramon; G Breen; MA Brown; R Bruggeman; NG Buccola; RL Buckner; M Budde; B Bulik-Sullivan; SJ Bumpstead; W Bunney; M Burmeister; JD Buxbaum; J Bybjerg-Grauholm; W Byerley; W Cahn; G Cai; MJ Cairns; D Campion; RM Cantor; VJ Carr; N Carrera; JP Casas; M Casas; SV Catts; P Cervantes; KD Chambert; RCK Chan; EYH Chen; RYL Chen; W Cheng; EFC Cheung; SA Chong; TK Clarke; CR Cloninger; D Cohen; N Cohen; JRI Coleman; DA Collier; P Cormican; W Coryell; N Craddock; DW Craig

Journal article

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

DM Ruderfer, S Ripke, A McQuillin, J Boocock, EA Stahl, JMW Pavlides, N Mullins, AW Charney, APS Ori, LMO Loohuis, E Domenici, A Di Florio, S Papiol, JL Kalman, V Trubetskoy, R Adolfsson, I Agartz, E Agerbo, H Akil, D Albani Show all

Cell | Published : 2018

DOI: 10.1016/j.cell.2018.05.046

Abstract

Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology. Understanding the genetic factors contributing to the shared and disorder-specific symptoms will be crucial for improving diagnosis and treatment. In genetic data consisting of 53,555 cases (20,129 bipolar disorder [BD], 33,426 schizophrenia [SCZ]) and 54,065 controls, we identified 114 genome-wide significant loci implicating synaptic and neuronal pathways shared between disorders. Comparing SCZ to BD (23,585 SCZ, 15,270 BD) identified four genomic regions including one with disorder-independent causal variants and potassium ion response genes as contributing to differences in biology between the disorder..

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University of Melbourne Researchers

Bernhard Baune Author

Christos Pantelis Author

Grants

Awarded by National Institute of Mental Health

Funding Acknowledgements

The work of the contributing groups was supported by numerous grants from governmental and charitable bodies as well as philanthropic donation. Specifically, D.M.R. (R01MH111776) and N.R.W. (NHMRC 1078901, 1087889).