New Pd/Pt(ii) complexes as unsymmetrical ylide-based chemotherapeutic agents: Synthesis, characterization, biological activity, electrochemical, and X-ray studies

Abstract

New Pd/Pt-complexes were synthesized by incorporating α-keto stabilized unsymmetrical phosphorus ylides [Ph2P(CH2)nPPh2C(H)C(O)C6H4-p-Ph] (n = 1, (Y1); n = 2, (Y2)) and M(Cod)Br2 (M = Pt, Pd; Cod = 1,5-cyclooctadiene). The obtained P,C-chelated [PdBr2(κ2-Y1)] (1), [PtBr2(κ2-Y1)] (2), [PdBr2(κ2-Y2)] (3), and [PtBr2(κ2-Y2)] (4) complexes were characterized successfully by FT-IR and NMR (1H, 13C, and 31P) spectroscopic methods. The structures of 1, 2, and 3 were elucidated by single crystal X-ray structural analyses. The structures of 1 and 2 consist of five-membered rings, while that of 3 has a six-membered ring, formed by coordination of the ligand with the phosphine group and the ylidic carb..