Journal article

Childhood Respiratory Risk Factor Profiles and Middle-Age Lung Function: A Prospective Cohort Study from the First to Sixth Decade

Dinh S Bui, Haydn E Walters, John A Burgess, Jennifer L Perret, Minh Q Bui, Gayan Bowatte, Adrian J Lowe, Melissa A Russell, Bruce R Thompson, Garun S Hamilton, Alan L James, Graham G Giles, Paul S Thomas, Debbie Jarvis, Cecilie Svanes, Judith Garcia-Aymerich, Bircan Erbas, Peter A Frith, Katrina J Allen, Michael J Abramson Show all



RATIONALE: Childhood risk factors for long-term lung health often coexist and their specific patterns may affect subsequent lung function differently. OBJECTIVES: To identify childhood risk factor profiles and their influence on lung function and chronic obstructive pulmonary disease (COPD) in middle age, and potential pathways. METHODS: Profiles of 11 childhood respiratory risk factors, documented at age 7, were identified in 8,352 participants from the Tasmanian Longitudinal Health Study using latent class analysis. We investigated associations between risk profiles and post-bronchodilator lung function and COPD at age 53, mediation by childhood lung function and adult asthma, and interact..

View full abstract


Awarded by National Health and Medical Research Council (NHMRC) of Australia - European Union

Funding Acknowledgements

Supported by the National Health and Medical Research Council (NHMRC) of Australia under NHMRC project grant schemes 299901 and 1021275, and NHMRC European collaborative grant scheme 1101313 as part of ALEC (Ageing Lungs in European Cohorts funded by the European Union's Horizon 2020 Research and Innovation Programme under grant agreement No. 633212); the University of Melbourne; the Clifford Craig Medical Research Trust of Tasmania; the Victorian, Queensland, and Tasmanian Asthma Foundations; the Royal Hobart Hospital; the Helen MacPherson Smith Trust; and GlaxoSmithKline.