Journal article
Xpert MTB/RIF assay did not improve diagnosis of pulmonary tuberculosis among child contacts in Rwanda
FM Birungi, B van Wyk, J Uwimana, J Ntaganira, SM Graham
Pan African Medical Journal | AFRICAN FIELD EPIDEMIOLOGY NETWORK-AFENET | Published : 2018
Abstract
Introduction: To report on the diagnostic yield using the Xpert MTB/RIF assay on gastric lavage samples from children (<15 years) who were household contacts of tuberculosis (TB) cases in Kigali, Rwanda. Methods: A cross-sectional study was conducted among 216 child contacts of index cases with sputum smear-positive TB over a 7 month period, from 1st August 2015 to 29th February 2016. Child contacts with tuberculosis-related symptoms or abnormal chest X-ray had sputum collected by gastric lavage on two consecutive days and samples were examined by smear microscopy, Xpert MTB/RIF assay and solid culture. Results: Of the 216 child contacts, 94 (44%) were less than 5 years of age. Most of them ..
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Funding Acknowledgements
We would like to express our sincere gratitude to study participants and their parents or caregivers, TB diagnostic laboratory staff, TB focal points, head of PHCs, Community health workers and data enumerators involved in this study. We thank also Jino Bahemuka and Mary Nellima Ondiaka for editing the manuscript. We also thank the Swedish International Development + Agency (Sida) that funded this study through University of Rwanda Coordination office of Research Activities (UR-CRA). We declare that the funder has no role in the study design, data collection and analysis, preparation of the manuscript and decision to publish.