Journal article

Significant variation between SNP-based HLA imputations in diverse populations: the last mile is the hardest

DJ Pappas, A Lizee, V Paunic, KR Beutner, A Motyer, D Vukcevic, S Leslie, J Biesiada, J Meller, KD Taylor, X Zheng, LP Zhao, P-A Gourraud, JA Hollenbach, SJ Mack, M Maiers

PHARMACOGENOMICS JOURNAL | NATURE PUBLISHING GROUP | Published : 2018

University of Melbourne Researchers

Grants

Awarded by Office of Naval Research (ONR)


Awarded by National Institutes of Health (NIH) - National Institute of Allergy and Infectious Diseases (NIAID)


Awarded by National Institutes of Health (NIH) - National Institute of General Medical Sciences (NIGMS)


Awarded by National Multiple Sclerosis Society (NMSS)


Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by Victorian Life Sciences Computation Initiative (VLSCI)


Funding Acknowledgements

We thank Janelle Noble, Marc Salit and P Scott Pine for helpful discussions and Abeer Madbouly for assistance with the PCA plots. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH, NIAID, NINDS, NMSS, ONR or United States Government. This work was supported by Office of Naval Research (ONR) grant N00014-08-1-1207 (KB, DP, PAG, JAH, AL, SJM, MM and VP), National Institutes of Health (NIH) grants U01AI067068 (JAH and SJM) and U19AI067152 (ARRA administrative supplement) (PAG) awarded by the National Institute of Allergy and Infectious Diseases (NIAID), R01GM109030 (JAH, SJM and DJP) and P01GM099568 (XZ) awarded by the National Institute of General Medical Sciences (NIGMS), RO1NS076492 (PAG), RO1NS046297 (PAG) and R01NS049477 (PAG) awarded by the National Institute of Neurological Disorders and Stroke (NINDS), and National Multiple Sclerosis Society (NMSS) grant RG 2899-D11 (PAG). PAG is a recipient of the Race to Erase MS Junior Investigator Award and the European Federation for Immunogenetics Julia Bodmer Award. This work was supported by the Australian National Health and Medical Research Council (NHMRC), Career Development Fellowship ID 1053756 (S.L.); and by the Victorian Life Sciences Computation Initiative (VLSCI) grant number VR0240 on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government, Australia (S.L.). Research at the Murdoch Childrens Research Institute was supported by the Victorian Government's Operational Infrastructure Support Program. We thank President Barack H. Obama for his support and appreciation of American science and basic research.