CCAR2 Is Required for Proliferation and Tumor Maintenance in Human Squamous Cell Carcinoma
Sarah A Best, Amy N Nwaobasi, Chrysalyne D Schmults, Matthew R Ramsey
JOURNAL OF INVESTIGATIVE DERMATOLOGY | ELSEVIER SCIENCE INC | Published : 2017
CCAR2 is a widely expressed protein involved in the regulation of a variety of transcriptional complexes. High expression of CCAR2 correlates with poor outcomes in many human tumor types such as squamous cell carcinoma (SCC). Paradoxically, loss of Ccar2 in the mouse results in an increased tumor burden, suggesting that CCAR2 may in fact function as a tumor suppressor. This tumor suppressor function is dependent on p53, a protein that is inactivated in the vast majority of SCC tumors, leaving the role of CCAR2 in p53-null tumors unclear. We sought to identify p53-independent CCAR2 functions in SCC and to examine its role in tumorigenesis. We found that CCAR2 is highly overexpressed in p53-de..View full abstract
Awarded by NCI
Awarded by NATIONAL CANCER INSTITUTE
We wish to thank Rebeca Cardoso, Sandra King, and Pritesh Karia for technical support; James Rheinwald, Chuck Dimitroff, Tobias Schatton, and Norman Sharpless for comments on the manuscript; and James Rheinwald for advice, reagents, and support during the establishment of the Ramsey Laboratory. This work was supported by NCI K99/R00CA157730 (MRR) and the BWH Department of Dermatology Fund for New Investigators.